Common Jaundice, Hepatitis (viral infection of liver), Increased liver enzymes, Joint pain.

Expert advice for Actizid Tablet

Avoid alcoholic beverages while taking this drug.
Do not have any immunizations/vaccinations while using this medication without the consent of your doctor.
Contact your doctor immediately if you experience symptoms such as persistent nausea,  vomiting, feeling of discomfort (malaise) or jaundice (abnormal liver function causing yellowing of skin and eyes) while taking pyrazinamide. It indicates that you are developing liver disease.
Constant monitoring of liver function (especially levels of enzymes aspartate transferase [AST] and alanine transferase [ALT]) and blood uric acid levels is advised while on treatment with pyrazinamide.
Do consult your doctor before taking pyrazinamide if you are pregnant or planning to become pregnant.
Do not use pyrazinamide, if you are breast-feeding.
Do not stop taking pyrazinamide without consulting your doctor.
If you forget to take a dose of pyrazinamide, take it as soon as you remember. Do not double the dose to make up for the missed dose.
Do consult your doctor if you are taking oral contraceptive medications (hormonal birth control pills) for birth control. Your doctor may ask you to use other means of birth control (eg. condom, diaphragm with spermicide) to prevent pregnancy while taking pyrazinamide.

Q. What is Actizid and what is it used for?
Actizid is an antibiotic. It is used in combination with other antibiotics in the treatment of tuberculosis

Q. Is Actizid bactericidal?
Actizid is both a bacteriostatic and a bactericidal antibiotic. It stops the growth of bacteria (bacteriostatic) in certain cases and kills (bactericidal) the tuberculosis causing bacteria in other cases

Q. How does Actizid work/treat tuberculosis?
Actizid kills or stops growth of bacteria that causes tuberculosis (Mycobacterium tuberculosis). The exact mechanism of action for Actizid is not known

Q. How does Actizid cause hyperuricemia and gout?
Following oral intake of Actizid, it gets converted in the body to pyrazinoic acid (active chemical form of Actizid). Pyrazinoic acid blocks the excretion of urates (salt form of uric acid) by the kidneys. This causes an increase in blood levels of uric acid (hyperuricemia). Excess uric acid accumulation between joints causes pain, swelling, redness and stiffness in joints (gout).