Zyrifa Capsule 
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NOTICE: unsafe with : Alcohol
USED FOR:
Tuberculosis (TB)
COMPOSITION:
Isoniazid (NA) + Rifampicin (NA) + Ethambutol (NA) + Pyrazinamide (NA)
Therapeutic Uses:
anti infectives
CAUTION
Zyrifa Capsule may cause symptoms such as flushing, increased heartbeat, nausea, thirst, chest pain and low blood pressure with alcohol (Disulfiram reactions).
WEIGH RISKS VS BENEFITS
Zyrifa Capsule may be unsafe to use during pregnancy.Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Zyrifa Capsule is probably safe to use during lactation. Limited human data suggests that the drug does not represent a significant risk to the baby.
Do not drive unless you are feeling well.Zyrifa Capsule occasionally causes sight problems and tingling or numbness in hand or feet. After taking this medicine you should not drive until you know how it affects you.
CAUTION
Zyrifa Capsule should be used with caution in patients with kidney disease. Dose adjustment of Zyrifa Capsule may be needed. Please consult your doctor.Kidney function tests are advisable before the start of this medicine.
CAUTION
Zyrifa Capsule should be used with caution in patients with liver disease. Dose adjustment of Zyrifa Capsule may be needed. Please consult your doctor.Regular monitoring of liver function tests is advised before and after the start of the treatment.
Uses of Zyrifa Capsule
Zyrifa Capsule is used in the treatment of tuberculosis.
How to use Zyrifa Capsule
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zyrifa Capsule may be taken with or without food, but it is better to take it at a fixed time.Avoid Zyrifa Capsule with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.
How Zyrifa Capsule works
Zyrifa Capsule is a combination of four medicines: Isoniazid, rifampicin, ethambutol and pyrazinamide which treat tuberculosis. Isoniazid works by preventing the TB bacteria from forming their own protective covering, while rifampicin inactivates a bacterial enzyme (RNA-polymerase) which is required by TB bacteria to make essential proteins and to reproduce. Together, they kill the bacteria and eradicate the infection. Ethambutol and pyrazinamide, on the other hand work by slowing the growth of these bacteria.
Common Nausea, Vomiting, Rash, Fever, Dark colored urine, Sweating, Increased sputum production, Salivation, Teary eyes, Peripheral neuropathy (tingling and numbness of feet and hand), Increased liver enzymes, Jaundice, Increased uric acid level in blood, Visual impairment.
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