Duotax 500 mg/250 mg Injection 
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USED FOR:
Bacterial infections
COMPOSITION:
Cefotaxime (500mg)
Sulbactam (250mg)
Therapeutic Uses:
anti infectives
Interaction with alcohol is unknown. Please consult your doctor.
PROBABLY SAFE
Duotax 500 mg/250 mg Injection is probably safe to use during pregnancy.Animal studies have shown low or no adverse effect on the foetus, however, there are limited human studies. Please consult your doctor.
SAFE
Duotax 500 mg/250 mg Injection is safe to use during lactation. Human studies have shown that either the drug does not pass into the breastmilk in significant amount or is not expected to cause toxicity to the baby.
Duotax 500 mg/250 mg Injection may make you feel dizzy, sleepy, tired, or decrease alertness. If this happens, do not drive.
CAUTION
Duotax 500 mg/250 mg Injection should be used with caution in patients with kidney disease. Dose adjustment of Duotax 500 mg/250 mg Injection may be needed. Please consult your doctor.Regular monitoring of kidney function may be advised while you are taking this medicine.
There is limited information available on the use of Duotax 500 mg/250 mg Injection in patients with liver disease. Please consult your doctor.
Uses of Cefotaxime
Cefotaxime is used in the treatment of bacterial infectionsIt is used for short-term treatment of bacterial infections of urinary tract, skin and soft-tissue, ear, bone, blood, abdomen, genital and lungs (pneumonia). It is also used to prevent infections after surgery.
How to use Cefotaxime
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Duotax 500 mg/250 mg Injection works
Cefotaxime is an antibiotic. It works by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria in the human body.
Common Nausea, Diarrhoea, Allergic reaction.
Expert advice for Cefotaxime
Your doctor has prescribed Cefotaxime to cure your infection and improve symptoms. Do not skip any doses and finish the full course of treatment even if you feel better. Discontinue Cefotaxime and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing. Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn't stop or if you find blood in your stools. If you're on blood thinners, Cefotaxime can interact with your medications and increase your bleeding tendencies.
Q. Is cefotaxime a sulfa, penicillin or broad spectrum antibiotic?
Cefotaxime does not contain sulfa and is not a penicillin drug. It is a third generation, broad spectrum cephalosporin antibiotic
Q. Is cefotaxime compatible with potassium and TPN?
Yes, cefotaxime can be given with potassium and TPN (total parenteral nutrition)
Q. Is Cefotaxime ototoxic (toxic to the ear)?
No, Cefotaxime is not an ototoxic drug when given alone, but when given along with aminoglycoside antibiotics (gentamicin, tobramycin), it may increase ototoxicity
Q. Is Cefotaxime bacteriostatic or bactericidal?
Cefotaxime is a bactericidal agent
Q. What organisms does Cefotaxime cover?
Cefotaxime is active against Escherichia coli, group A and B streptococci, pseudomonas and staphylococcus bacteria. In some cases, Streptococcus pneumonia may show resistance to the drug. It may not be effective against methicillin- resistant Staphylococcus aureus (MRSA).
Uses of Sulbactam
Sulbactam is used in the treatment of bacterial infections.
How to use Sulbactam
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Duotax 500 mg/250 mg Injection works
Sulbactam blocks the action of the enzymes produced by bacteria to inactivate the antibiotics.
Common Vomiting, Nausea, Diarrhoea, Abdominal pain, Jaundice, Abnormal liver function tests, Allergic reaction, Hives, Redness of skin, Ankle swelling, Limb swelling, Difficulty in swalloing, Shortness of breath, Facial swelling, Skin swelling, Tongue swelling, Throat swelling, Injection site bruising, Injection site bleeding, Stomach cramp, Wheezing.
Expert advice for Sulbactam
It is preferentially given as an injection directly into a vein or into a muscle but tablet form is also available.
Tell the doctor if you have diabetes and regularly check your urine for sugar level; ampicillin and sulbactam may cause false positive results.
Do not start or continue the sulbactam and consult your doctor: If you have asthma, runny nose due to allergy (hay fever), or kidney or gastrointestinal disease especially inflammation of large intestine (colitis), If you are pregnant or planning to become pregnant or breastfeeding or become pregnant while taking ampicillin and sulbactam.
Q. Is Sulbactam a sulfa (sulfonamide) drug?
Sulbactam does not contain sulfa. It is a semisynthetic beta lactamase Inhibitor
Q. What is Sulbactam sodium?
Sulbactam is a beta-lactamase inhibitor used as the sodium salt to increase the antibacterial activity of penicillins
Q. Is Sulbactam safe?
Sulbactam is relatively safe if used at prescribed doses for the prescribed duration as advised by your doctor.
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