Common Fever, Blood in urine, Hair loss, Urinary tract infection, Mucosal inflammation, Decreased white blood cell count (neutrophils), Infection, Bone-marrow suppression.

Expert advice for Endoxan Injection

Monitor your blood counts with the help of regular blood tests while on treatment with cyclophosphamide.
Contact your doctor immediately if you experience difficulty in urinating, blood in urine or any other bladder/ kidney related problems while on treatment with cyclophosphamide.
Do not start treatment with cyclophosphamide if you are planning to receive any vaccine or if you have a surgery scheduled or you have had a surgical removal of the adrenal glands.
Take precautions as treatment with cyclophosphamide severely affects your immune system, increasing susceptibility to infections (e.g. pneumonia).
Caution must be exercised during use of cyclophosphamide in very ill patients, patients with kidney/liver disorders, lung problems and heart problems (related to QT prolongation and abnormal heartbeats).

Q. Is Endoxan chemotherapy?
It is toxic to cancer cells and interferes with the cell's DNA synthesis, thus slowing down or stopping its growth and multiplication (cytotoxic effect)

Q. Is Endoxan prodrug?
Yes. Endoxan is administered in the inactive form (prodrug) and gets converted to active form which has anti-cancer properties

Q. Does Endoxan have a boxed warning?
No. Endoxan does not have any specific boxed warning. Please discuss with your doctor about all the possible side effects and warnings relating to use of Endoxan

Q. Does Endoxan come in liquid form?
No. Endoxan comes in a dry powder form that be reconstituted to make a solution for injection or oral liquid as directed

Q. Is Endoxan a cytotoxic drug?
Yes. Endoxan is chemotherapy and a cytotoxic drug used in the treatment of various cancers

Q. Is Endoxan an antimetabolite/ steroid/ anthracycline?
No. Endoxan is an alkylating agent used in the treatment of various cancers. It is not an antimetabolite or anthracycline type of anti-cancer drug. It has a structure and effects different from steroids

Q. Is Endoxan a vesicant?
Endoxan is an irritant and can cause tissue inflammation at site of injection if its oozes out of the vein

Q. Does Endoxan cause hair loss/ infertility/ thrombocytopenia/ headaches/ hemorrhagic cystitis?
Yes. Hair loss (alopecia), infertility (in men and women), low platelet count (thrombocytopenia), headaches and inflammation of the urinary bladder (hemorrhagic cystitis) are among the known common side effects of Endoxan use

Q. Is Endoxan removed by plasma exchange?
Endoxan is unlikely to be removed by plasma exchange since a very low percentage of drug is bound to proteins in the plasma.