Side Effects:

Common Nausea, Headache, Skin rash, Loss of appetite, Increased body temperature.

Expert advice for Sazo EN Tablet
You have been prescribed Sazo en to control the symptoms and slow down the progression of inflammatory bowel disease or rheumatoid arthritis. You may have to wait for 6 to 12 weeks to get the full effect. Drink plenty of water while on Sazo en. This will prevent kidney stone and kidney damage. You may experience loss of appetite and nausea on starting Sazo en. Your urine may change color (to orange). Do not worry if that happens. Avoid contact with people who have cold, flu or other contagious illness. Notify your doctor if you have any signs of infection such as a fever or sore throat. Inform your doctor if you ever had any form of drug allergy. Inform your doctor if you are pregnant or planning to conceive or breastfeeding. Inform your doctor if you are suffering from any blood disease e.g. G6PD deficiency.

Frequently Asked Questions

Q. Is Sazo en a DMARDs?
Yes, Sazo en is a DMARDs (Disease-Modifying Antirheumatic Drugs). It prevents joint damage and preserves joint mobility.

Q. Can I use Sazo en 1gram BD?
Yes, Sazo en can be used as 1gm BD (twice daily) if you have severe disease.

Q. How is Sazo en metabolized?
Sazo en is metabolized in the colon by the bacterial enzyme azoreductase to sulfapyridine and 5 aminosalicylic acid (5-ASA).

Q. How long does Sazo en take to produce the effect?
Sazo en does not work right away. It will take about 6 to 12 weeks to get the full effect.

Q. Where is sulfasalazine absorbed?
Sazo en is absorbed in the intestine (jejunum and colon). In the colon, it breaks down to sulfapyridine and 5 aminosalicylic acid (5-ASA).

Q. Can I use Sazo en with hepatitis B?
Yes, Sazo en is relatively safe in hepatitis B infection.

Q. Can I use Sazo en in hepatitis C?
Sazo en should not be used in hepatitis C patients with bad prognosis.

Q. Sazo en for alopecia areata?
Sazo en is not approved for treatment of alopecia areata.

Q. Sazo en for gout?
Sazo en is not approved for treatment of gout.

Q. Sazo en for IBS (irritable bowel syndrome)?
Sazo en is not approved for treatment of irritable bowel syndrome (IBS).

Q. Sazo en for IBD(inflammatory bowel disease)?
Yes, Sazo en is used in the treatment of inflammatory bowel disease (IBD).

Q. Sazo en for psoriatic arthritis?
Sazo en is a DMARD that may be effective for the joint pain and skin lesions associated with psoriatic arthritis.

Q. Sazo en for psoriasis?
Sazo en is not approved for psoriasis.

Q. Can I use Sazo en with vitamin c?
Yes, Sazo en can be used with vitamin c.

Q. Can I use Sazo en with vitamin d?
Yes, Sazo en can be used with vitamin d.

Q. Sazo en vs mesalamine?
Mesalamine and Sazo en are both used in the treatment of ulcerative colitis. Sazo en having fewer side effects as compared to mesalamine.

Q. Sazo en vs balsalazide?
Balsalazide has a better tolerability than Sazo en in patients with ulcerative colitis.

Q. Sazo en with folic acid?
Sazo en inhibits the absorption and metabolism of folic acid.which may cause folic acid deficiency. This can result in serious blood disorders (e.g., macrocytosis and pancytopenia). This can be normalized by administration of folic acid or folinic acid (leucovorin).

Q. Sazo en interaction with methotrexate?
Coadministration of Sazo en and methotrexate do not alter the pharmacokinetic disposition of the drugs. It may increase the incidence of gastrointestinal adverse events, especially nausea.

Q. Sazo en with meloxicam?
Meloxicam and Sazo en cause kidney problem if given together.

Q. Sazo en with antibiotics?
People who are allergic to sulfa drugs antibiotics like cotrimoxazole, sulfisoxazole etc, may have a cross reaction to Sazo en and should therefore not take it.

Q. Sazo en with prednisone?
Sazo en can be given in conjunction with steroids (prednisone) as part of an intensive management regime during the severe attack of rheumatoid arthritis.

Q. Sazo en with adalimumab?
Adalimumab can be used with Sazo en in the treatment of moderate to severe, active rheumatoid arthritis in adult patients when the response to disease-modifying antirheumatic drugs (DMARDs) is inadequate.

Q. Sazo en with the sulfa allergy?
Patients with sulfa drug allergy should avoid Sazo en.

Q. Sazo en with naproxen?
Sazo en is used in the treatment of rheumatoid arthritis who has failed to respond to non-steroidal anti-inflammatory drugs (NSAIDs) e.g naproxen.

Q. Sazo en with ibuprofen?
Sazo en is used in the treatment of rheumatoid arthritis who has failed to respond to non-steroidal anti-inflammatory drugs (NSAIDs) e.g ibuprofen.

Q. Sazo en with methotrexate side effects?
Taking Sazo en and methotrexate together may increase the incidence of gastrointestinal adverse events, especially nausea.

Q. Sazo en with hydroxychloroquine?
Sazo en and hydroxychloroquine combination have shown better and faster response in rheumatoid arthritis.

Q. Allergic to Sazo en?
You should not take Sazo en, if you are allergic to Sazo en.

Q. Is Sazo en a prodrug?
Yes, Sazo en is a prodrug. It gets converted into sulfonamide (sulfapyridine) and 5 aminosalicylic acid (5-ASA) in the body.

Q. Is Sazo en a sulfa drug?
Yes, Sazo en is a sulfa drug because it contains sulfonamide (sulfapyridine) as active ingredients.

Q. Is Sazo en an antibiotic?
Sazo en is a combination of antibiotic sulfapyridine and 5 aminosalicylic acid, mainly used in inflammatory bowel disease and rheumatoid arthritis.

Q. Is Sazo en enteric coated?
Some formulation of Sazo en may be available as enteric-coated. Enteric coating is done to prevent the tablet destruction by stomach acid.

Q. Sazo en causes weight loss?
Yes, Sazo en can cause loss of appetite which may lead to loss of weight.

Q. Can Sazo en cause rash?
Yes, Sazo en can cause the rash as a side effect.

Q. What is the Sazo en drug class?
Sazo en belongs to sulfonamide drug class.

Q. What is Sazo en delayed-release tablets?
Sazo en delayed release tablets are the enteric coated tablets, which prevent the disintegration of the drug when they come in contact with stomach acid.

Q. Sazo en cause insomnia?
Yes, Sazo en can cause insomnia as a side effect.

Q. Sazo en flu-like symptoms?
Sazo en can cause flu-like symptoms like aching of joints, fever, headache, sore throat, rashes.

Q. Sazo en for ulcerative colitis?
Ulcerative colitis is an inflammatory bowel disease. Sazo en releases 5 aminosalicylic acid which decreases inflammation of the intestines and thus helpful in ulcerative colitis.

Q. Sazo en for Crohn's disease?
Crohn's disease is an inflammatory bowel disease. Sazo en releases 5 aminosalicylic acid which decreases inflammation of the intestines and thus helpful in Crohn's disease.

Q. Sazo en in cancer patients?
Sazo en is not approved for treatment of cancer.

Q. Why does Sazo en cause blood disorders?
Sazo en inhibits the absorption and metabolism of folic acid. Which may cause folic acid deficiency. This can result in serious blood disorders (e.g., macrocytosis and pancytopenia).

Q. Why does Sazo en cause a sore throat?
Sazo en suppresses the immune system which can manifest with the sign of infections like a sore throat or fever.

Q. What does Sazo en contain?
Sazo en contains sulfonamide (sulfapyridine) and 5 aminosalicylic acid (5-ASA) as active ingredients.

Q. Side effects of stopping sulfasalazine?
If Sazo en is stopped, patient can experience withdrawal symptoms like depression, pain, stress, anxiety, back pain, and muscle spasticity.

Q. Sazo en withdrawal?
Sazo en withdrawal can cause depression, pain, stress, anxiety, back pain and muscle spasticity.