Taking metformin with alcohol can cause lactic acidosis and you may experience malaise, respiratory distress, slow or irregular heartbeat, sleepiness, stomach upset, or other unusual symptoms.

Safe Gem 1mg Tablet may be unsafe to use during pregnancy.Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.

Safe Gem 1mg Tablet is probably safe to use during lactation. Limited human data suggests that the drug does not represent a significant risk to the baby.

Your ability to drive may be affected if your blood sugar is low or high. If this happens, do not drive.

Safe Gem 1mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Safe Gem 1mg Tablet may be needed. Please consult your doctor.Use of Safe Gem 1mg Tablet is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine.

Safe Gem 1mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Safe Gem 1mg Tablet may be needed. Please consult your doctor.Safe Gem 1mg Tablet is generally started with low dose in patients with mild to moderate liver disease and its use is not recommended in patients with severe liver disease.