Gramonex Injection 
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NOTICE: unsafe with : Alcohol
USED FOR:
Bacterial infections
COMPOSITION:
Nalidixic Acid (375mg)
Metronidazole (NA)
Therapeutic Uses:
gastro intestinal
CAUTION
Gramonex Injection may cause symptoms such as flushing, increased heartbeat, nausea, thirst, chest pain and low blood pressure with alcohol (Disulfiram reactions).
WEIGH RISKS VS BENEFITS
Gramonex Injection may be unsafe to use during pregnancy.Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
CAUTION
Gramonex Injection should be used with caution during lactation. Breast feeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.If a single dose of Gramonex Injection is used, it is recommended to hold breastfeeding for 12-24 hours to allow the removal of the drug.
Do not drive unless you are feeling well.Gramonex Injection may make you feel sleepy, dizzy, confused. You may have hallucinations, fits (convulsions) or temporary eyesight problems (such as blurred or double vision) affecting your ability to drive.
CAUTION
Gramonex Injection should be used with caution in patients with kidney disease. Dose adjustment of Gramonex Injection may be needed. Please consult your doctor.Regular monitoring of kidney function tests is advised if this medicine is to be taken for a long time.
CAUTION
Gramonex Injection should be used with caution in patients with liver disease. Dose adjustment of Gramonex Injection may be needed. Please consult your doctor.
Uses of Nalidixic Acid
Nalidixic Acid is used in the treatment of bacterial infectionsIt is also used in infections of urinary tract, tonsils, sinus, nose, throat, female genital organ, skin and soft tissues, windpipe and lungs (pneumonia).
How to use Nalidixic Acid
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Gramonex Injection works
Nalidixic Acid is an antibiotic. It kills bacteria by preventing them from reproducing and repairing themselves. This treats your infection.
Common Nausea, Diarrhoea, Allergic reaction.
Expert advice for Nalidixic Acid
Your doctor has prescribed Nalidixic Acid to cure your infection and improve symptoms. Do not skip any doses and finish the full course of treatment even if you feel better. Discontinue Nalidixic Acid and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing. Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn't stop or if you find blood in your stools. Notify your doctor if you feel pain in your tendons, numbness, or tingling sensations. Inform your doctor if you are pregnant or planning to conceive or breastfeeding.
Q. How does Nalidixic Acid work/ inhibit bacterial growth /inhibit DNA synthesis?
It works by killing the bacteria that are causing an infection. It does this by entering the bacterial cells and inhibiting a bacterial enzyme called DNA-gyrase
Q. How does Nalidixic Acid inhibit DNA synthesis?
Nalidixic Acid acts by inhibiting DNA synthesis, probably by interfering with DNA polymerisation.
Q. Is Nalidixic Acid an antibiotic / quinolone / broad spectrum / fluoroquinolone?
Yes, Nalidixic Acid is a broad spectrum quinolone antibiotic
Q. What does Nalidixic Acid target?
It stops the production of essential proteins needed by bacteria
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