Taking metformin with alcohol can cause lactic acidosis and you may experience malaise, respiratory distress, slow or irregular heartbeat, sleepiness, stomach upset, or other unusual symptoms.

Istamet 50mg/500mg Tablet is probably safe to use during pregnancy.Animal studies have shown low or no adverse effect on the foetus, however, there are limited human studies. Please consult your doctor.

Istamet 50mg/500mg Tablet is probably safe to use during lactation. Limited human data suggests that the drug does not represent a significant risk to the baby.

Your ability to drive may be affected if your blood sugar is low or high. If this happens, do not drive.

Istamet 50mg/500mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Istamet 50mg/500mg Tablet may be needed. Please consult your doctor.Use of Istamet 50mg/500mg Tablet is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine.

Istamet 50mg/500mg Tablet is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Istamet 50mg/500mg Tablet may not be needed in these patients. Please consult your doctor.