NOTICE: unsafe with : Alcohol Pregnancy
USED FOR:
Hormone replacement therapy
Erectile dysfunction
Post menopausal osteoporosis
COMPOSITION:
Estradiol (2mg)
Sildenafil (25mg)
Therapeutic Uses:
gynaecological
sex stimulants rejuvenators
Taking Sildenafil with alcohol may lower blood pressure.
Primiwal 2 mg/25 mg Tablet is highly unsafe to use during pregnancy.Human and animal studies have shown significant adverse effects on the foetus. Please consult your doctor.
Primiwal 2 mg/25 mg Tablet is probably safe to use during lactation. Limited human data suggests that the drug does not represent a significant risk to the baby.
Primiwal 2 mg/25 mg Tablet may make you feel dizzy, drowsy or affect your vision. Do not drive until your vision is clear.
Primiwal 2 mg/25 mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Primiwal 2 mg/25 mg Tablet may be needed. Please consult your doctor.
Primiwal 2 mg/25 mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Primiwal 2 mg/25 mg Tablet may be needed. Please consult your doctor.Use of Primiwal 2 mg/25 mg Tablet is not recommended in patients who previously had liver disease and the liver function tests are still not normal.
Uses of Estradiol
Estradiol is used for hormone replacement therapy, post menopausal osteoporosis and contraception.
How to use Estradiol
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it.
How Primiwal 2 mg/25 mg Tablet works
Estradiol is a form of estrogen, a female sex hormone produced by the ovaries. It acts by replacing the natural hormone in the body when the latter is deficient.
Common Headache, Nausea, Mood changes, Change in body weight, Sexual dysfunction, Breast tenderness, Breast enlargement, Abdominal pain, Metrorrhagia (menstrual bleeding at irregular intervals), Edema, Fibroid.
Expert advice for Estradiol
The drug can cause nausea, vomitting or breast tenderness.
Do not use estradiol patches over breast stop taking estradiol and see a doctor immediately if you notice any of the following when taking estradiol:
yellowing of your skin or the whites of your eyes (jaundice).
rise in your blood pressure (symptoms may be headache, tiredness, dizziness).
new onset migraine-like headaches.
pregnancy.
signs of a blood clot, such as: painful swelling and redness of the legs, sudden chest pain, difficulty in breathing.
Do not consider estradiol alone as a contraceptive. It must be used with progestogen to provide contraceptive benefits.
Consult your doctor if you have unusual vaginal bleeding while taking this drug, Immediately consult your doctor if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision. This medicine should not be taken for a very long period.
Consult your doctor from time to time to check if you still need it.
Q. Is estradiol and estrogen the same/ is estradiol the same as progesterone/ is estradiol a synthetic hormone/does estradiol valerate work/ what is evalon cream?
Estradiol is the most potent natural estrogen (or “estrogen”) produced by ovaries in female. It is different from another female hormone that is progesterone. It is not a conjugated estrogen and it not a synthetic hormone. Estradiol valerate and Evalon vaginal cream works same as estradiol
Q. Can I take estrogen for polycystic ovary syndrome (PCOS)?
Polycystic ovary syndrome (PCOS) is mainly a result of hormonal disturbance in which there are high levels of male hormones in the body. Oral contraceptive pills containing low dose estrogen and progestogen are commonly prescribed to reduce the levels of endogenous hormone, which helps regularize the menstrual cycle, reduce male hormone levels and decrease acne associated with PCOS. Always consult your doctor before using any medication
Q. What can I take for estrogen dominance?
A balanced diet, exercise, a healthy life style and less exposure to environmental pollutants is what works best to restore the normal hormone balance and reduce estrogen dominance. Your doctor may also start a progesterone therapy, compounds that promote bile secretion, lipotropic formulas (excrete extra estrogen from body), substance which deactivate toxic substances and excess hormones to remove extra estrogen from your body
Q. What can I take for estrogen deficiency?
For estrogen deficiency, treatment is based on the underlying cause. Your doctor may choose from a variety of medications depending upon your condition for e.g. young or old with menopause, estrogen deficiency or high progesterone levels, etc. You may be given bio-identical estradiol or estriol or counterbalance with natural progesterone in the form of micronized capsules, etc
Q. Can I take estrogen forever?
The length of necessity of hormone therapy varies from person to person and the condition for which it is being treated for
Q. Is estradiol safe/ stop your period/ increase libido/cause constipation/ cause high blood pressure/ make you sleepy/ cause blood clots/ cause insomnia/ cause bloating/ make you emotional?
Estradiol is safe if used at recommended dosage and duration. Estradiol can stop your periods. It may cause high blood pressure and blood clots on long-term use. Other side effects are not confirmed but may occur with some patients. Consult your doctor if you experience one of them
Q. Is estradiol gluten free?
Estradiol preparations are gluten free. However, as the content of excipients differs according to the manufacturer, please refer to the package insert of the particular preparation/brand that you have been prescribed
Q. Is estradiol a conjugated estrogen/ better than Premarin?
Estradiol is a synthetic hormone, whereas Premarin contains conjugated estrogen. Both are different types of estrogen and have comparable benefit and side-effect profile.
Uses of Sildenafil
Sildenafil is used in the treatment of erectile dysfunction.
How to use Sildenafil
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it.
How Primiwal 2 mg/25 mg Tablet works
Sildenafil is a phosphodiesterase (PDE-5) inhibitor. It works by increasing blood flow to the penis by relaxing the muscles in penile blood vessels.
Common Headache, Diarrhoea, Dyspepsia, Flushing (sense of warmth in the face, ears, neck and trunk), Pain in extremity.
Expert advice for Sildenafil
Take it when you need it. Do not take more than once a day. It's best to take Sildenafil about 1 hour before sexual intercourse, but you can take it anywhere between 30 minutes and 4 hours before sexual activity. Sildenafil helps achieve and maintain an erection, but will not produce the erection without sexual stimulation. Do not use Sildenafil if you have recently taken nitrates (medicines used in angina or chest pain). Notify your doctor if the erection persists for more than two hours after sexual intercourse. Do not take Sildenafil if you recently had a stroke, a heart attack or if you have a serious liver disease or very low blood pressure (
Q. How does Sildenafil work?
Sildenafil is a phosphodiesterase 5 inhibitor which works by relaxing the penile smooth muscles and by increasing the blood flow to the penis. It helps to achieve and maintain an erection but only if there is sexual stimulation.
Q. Is Sildenafil safe?
Yes, Sildenafil is safe if taken for prescribed duration in prescribed doses as advised by your doctor. However, there are some very common side effects that you can experience at effective doses like Headache, Diarrhoea, Dyspepsia, Flushing (sense of warmth in the face, ears, neck and trunk), Pain in Extremity.
Q. Is Sildenafil a steroid?
No, Sildenafil is not a steroid. It belongs to a group of medicines called phosphodiesterase 5 inhibitors used for the treatment of erectile dysfunction.
Q. Is Sildenafil an over the counter product?
No, Sildenafil is not an over-the-counter product. You can buy it when it is prescribed by a doctor.
Q. Is Sildenafil a blood thinner?
No, Sildenafil is not a blood thinner. It belongs to a group of medicines called phosphodiesterase 5 inhibitors used for the treatment of erectile dysfunction.
Q. Can I take Sildenafil for premature ejaculation?
Sildenafil is not known to have any beneficial effects of treating premature ejaculation. It is used for the treatment of erectile dysfunction.
Q. Can I take Sildenafil for the rest of my life?
Sildenafil is a prescription drug and should only be taken for the duration as advised by your doctor.
Q. Can I take Sildenafil in my twenties?
Yes, Sildenafil can be taken in the twenties. It is approved for use in adult men above the age of 18 who have erectile dysfunction. It should be taken after consulting a doctor and strictly as advised.
Q. Can I take Sildenafil with dapoxetine?
Yes, Sildenafil can be safely taken with dapoxetine. Sildenafil is useful for treating erectile dysfunction and dapoxetine is for premature ejaculation. A fixed dose combination of these medicines is available which is useful in patients suffering from both erectile dysfunction and premature ejaculation. No drug-drug interactions or any harmful effects have been reported when they are used together.
Q. Can I take Sildenafil with warfarin?
Sildenafil can be taken with warfarin, no significant drug interactions have been seen between the two. However, there have been some clinical reports of penile fracture in patients using Sildenafil with warfarin. Inform your doctor before taking the two drugs together.
Q. Can I take Sildenafil if I am also having high blood pressure?
Sildenafil can be taken in patients with high blood pressure. However, if you are taking medicines for high blood pressure, taking Sildenafil along with them can cause a significant fall in blood pressure which could be harmful. Sildenafil is absolutely contraindicated in patients taking nitrates. Inform your doctor before taking them together.
Q. Can I take Sildenafil with lisinopril?
Yes, Sildenafil can be taken with lisinopril. However, there could be an excessive fall in blood pressure when taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken when taking both the drugs together and inform your doctor if you experience any of these symptoms.
Q. Can I take Sildenafil with ramipril?
Yes, Sildenafil can be taken with ramipril. However, there could be an excessive fall in blood pressure when taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken when taking both the drugs together and inform your doctor if you experience any of these symptoms.
Q. Can I take Sildenafil with beta blockers?
Yes, Sildenafil can be taken with beta-blockers. However, there could be an excessive fall in blood pressure when taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken when taking both the drugs together and inform your doctor if you experience any of these symptoms.
Q. Can I take Sildenafil with amlodipine?
Yes, Sildenafil can be taken with amlodipine. However, there could be an excessive fall in blood pressure when taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken when taking both the drugs together and inform your doctor if you experience any of these symptoms.
Q. Does Sildenafil affect fertility?
No, Sildenafil is not known to affect fertility. It is used only for erectile dysfunction. For treatment of any fertility-related problems, please consult a doctor.
Q. Does Sildenafil affect sperm?
Sildenafil is not known to affect sperm (number or movement of sperms). It is a drug which is used for erectile dysfunction.
Q. Does Sildenafil increase blood pressure?
No, Sildenafil is not associated with an increase in blood pressure. It can cause a decrease in blood pressure especially if taken with other blood-pressure-lowering medications. Please consult your doctor before taking Sildenafil with any other medicine.
Q. Does Sildenafil delay ejaculation?
No, Sildenafil is not known to affect ejaculation.
Q. Does Sildenafil expire?
Sildenafil like any other medicine has an expiry date and should not be used beyond the date mentioned on the package.
Q. Why does Sildenafil cause a fall in blood pressure (hypotension)?
Sildenafil has the property of relaxing the smooth muscle of the blood vessels and widening them which can cause a fall in blood pressure (hypotension). So, when used with blood pressure lowering drugs or nitrates, it can cause a severe fall in blood pressure, which could be fatal. Sildenafil should not be taken if you are taking nitrates for chest pain or you have a history of heart attack or stroke in the past six months.
Q. Is Sildenafil safe to use in patients with diabetes?
Yes, Sildenafil is safe to use in patients with diabetes. Erectile dysfunction and is commonly reported by diabetic patients as diabetes is one of the most common causes of this condition. Long standing diabetes can damage the nerves in the body (neuropathy) including the nerves of the penis. It also harden and narrow the blood vessels which decreases the blood flow to the penis causing erectile dysfunction. Sildenafil is seen to be beneficial in treating erectile dysfunction (ED) in patients with diabetes mellitus.
Q. Why is the use of Sildenafil contraindicated with nitrates?
Use of Sildenafil is not recommended in patients taking nitrates (organic nitrates or organic nitrites) as their combined use can cause a severe fall in blood pressure, which can also result in death. It is advisable to keep a time gap of 24 hours between the intake of Sildenafil and any nitrate substance.
Q. What are the serious side effects of Sildenafil?
Sildenafil can cause serious side effects like heart attack, sudden cardiac death, abnormal heart beat and bleeding in the brain tissues that can cause temporary or permanent brain damage. A patient can have chest pain during the intercourse and if this occurs, try to relax in a semi-sitting position and do not use any nitrate to relieve the chest pain. Rarely a sudden loss in vision and serious allergic skin reactions with fever, peeling and swelling of the skin, blistering of the mouth, genitals and around the eyes can occur.
Q. Can I take Sildenafil for treating piles (hemorrhoids)?
No, Sildenafil is not indicated for the treatment of piles (hemorrhoids). Rather, its use has been reported to cause piles (hemorrhoids).
Q. Can Sildenafil be taken with losartan?
Yes, Sildenafil can be taken along with losartan. However, there could be an excessive fall in blood pressure when taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken when taking both the drugs together and inform your doctor if you experience any of these symptoms.
Q. Can I take Sildenafil with paracetamol?
Yes, Sildenafil can be taken with paracetamol. No drug-drug interactions or any harmful effects have been reported when they are used together.
Q. Can I take Sildenafil with aspirin?
Yes, Sildenafil can be taken with aspirin. No drug-drug interactions or any harmful effects have been reported when they are used together.
Q. Can Sildenafil increase the level of testosterone?
Yes, Sildenafil can increase the testosterone levels. It has a direct effect on the testes which can lead to an increase in the blood testosterone levels.
Q. Can Sildenafil cause persistent and painful erection of the penis (priapism)?
Sildenafil and other drugs used for the treatment of erectile dysfunction have been seen to cause prolonged erections and persistent and painful erection of the penis(priapism). In case the erection persists for more than 4 hours, immediately seek medical attention. If it is not treated immediately, penile tissue damage and permanent loss of potency can occur.
Q. Can Sildenafil be taken with itraconazole?
Sildenafil can be taken with itraconzole, however, a dose adjustment would be needed before taking them together. Sildenafil is metabolized (degraded) by an enzyme known as CYP3A4. Itraconazole decreases the working of this enzyme causing increased blood levels of Sildenafil and higher chances of having side effects.
Q. Can I take Sildenafil with tadalafil?
Both tadalafil and Sildenafil are phosphodiesterase inhibitors and act by dilating the blood vessels. Using them together would not give any additional benefit, rather they may cause a severe fall in blood pressure and a prolonged painful erection. Therefore, these two drugs should not be taken together.
Q. What is the benefit of taking Sildenafil with finasteride?
Yes, Sildenafil can be taken along with finasteride. This combination is beneficial in the treatment of benign prostatic hyperplasia (BPH). Finasteride is also known to cause erectile dysfunction as one of its side effects and Sildenafil can be used for the treatment of this problem along with finasteride.
Q. Can I take Sildenafil with Tamsulosin?
Special caution needs to be taken when Sildenafil is taken along with Tamsulosin. Both are known to decrease blood pressure and can also cause orthostatic hypotension (fall in blood pressure when standing from a sitting position). So, when taken together they can cause a severe fall in blood pressure which can be harmful.
Q. Is Sildenafil a prescription medicine?
Yes, Sildenafil is a prescription medicine and can be taken only when prescribed by the doctor.
Q. Can I take Sildenafil for fun?
Sildenafil is a prescription drug and should only be taken for the appropriate indication as prescribed by a doctor as it may be associated with its own side effects.
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