Madopar Tablet 
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NOTICE: unsafe with : Alcohol
COMPOSITION:
Levodopa (200mg)
Benserazide (50mg)
Therapeutic Uses:
neuro cns
CAUTION
Madopar Tablet may cause excessive drowsiness and calmness with alcohol.
WEIGH RISKS VS BENEFITS
Madopar Tablet may be unsafe to use during pregnancy.Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
No information is available on the use of Madopar Tablet during lactation. Please consult your doctor.
Madopar Tablet may make you feel dizzy, sleepy, tired, or decrease alertness. If this happens, do not drive.
CAUTION
Madopar Tablet should be used with caution in patients with kidney disease. Dose adjustment of Madopar Tablet may be needed. Please consult your doctor.
CAUTION
Madopar Tablet should be used with caution in patients with liver disease. Dose adjustment of Madopar Tablet may be needed. Please consult your doctor.
Uses of Levodopa
Levodopa is used in the treatment of Parkinson's disease.
How to use Levodopa
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Madopar Tablet is to be taken with food.
How Madopar Tablet works
Levodopa works by being converted to dopamine, a chemical messenger that is needed to control the movement through transmission of signals in the brain.
Common Nausea, Vomiting, Dizziness, Loss of appetite, Orthostatic hypotension (sudden lowering of blood pressure on standing), Movement disorder.
Expert advice for Levodopa
If you are taking carbidopa with levodopa, do not take iron salts (eg, ferrous sulfate), within 2 hours before or a diet that is high in protein.
Avoid vitamin products that contain vitamin B6 (pyridoxine). This vitamin may reduce the effectiveness of levodopa.
Do not use levodopa, if you are allergic to levodopa or any other ingredient.
Do not use levodopa, if you have narrow-angle glaucoma; if you are suffering from malignant melanoma (a type of cancer); skin cancer or you have any unusual moles; severe mental disorder.
Do not take levodopa, if you have a history of fits (convulsions); heart problems or blood pressure problems; asthma or other lung problems; liver or kidney problems; blood or hormone (endocrine) problems; depression or any other psychiatric disorder; ulcer in your gut or have vomited blood or stomach or intestinal bleeding.
If you are undergoing any tests for urine glucose or urine ketones, levodopa may cause the results of some tests to be wrong.
Levodopa may cause drowsiness, dizziness, light-headedness or sudden sleep. Do not drive or use machinery while using it.
Do not take alcohol along with levodopa.
Q. Is levodopa a controlled substance/ a narcotic/ addictive/ lipid soluble/ a dopamine agonist/ a prodrug/ a monoamine oxidase inhibitor (MAOI)/ toxic/ an anticholinergic?
Levopoda is a lipid soluble prodrug that gets converted into dopamine when it crosses the blood brain barrier. It is not a dopamine agonist, controlled substance, narcotic, MAOI, toxic or anticholinergic. It may cause addiction in some patients
Q. Does Levodopa work/ stop tremors?
Levodopa is used to treat the symptoms of Parkinson's disease which includes tremors (shaking), stiffness, and slowness of movement. It works in most patients if taken at recommended dosage and duration
Q. Does Levodopa cause dyskinesia/ dementia/ accelerate Parkinson's disease/ get you high/stop cause constipation/ urine discoloration?
Levopoda may cause side effects such as constipation, a feeling of high in some patients
Q. Does Levodopa help with balance?
As Levodopa helps in controlling tremors,it can improve balancing in patients.
Uses of Benserazide
Benserazide is used in the treatment of Parkinson's disease.
How to use Benserazide
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Madopar Tablet is to be taken with food.
How Madopar Tablet works
Benserazide is always given with levodopa. It works by preventing levodopa from being broken down before it reaches the brain. This allows for a lower dose of levodopa, which causes less nausea and vomiting.
Common Nausea, Postural hypotension (low blood pressure), Psychiatric disturbances, Abnormal heart rhythm, Abnormal involuntary movements, Altered libido, Anemia, Drowsiness, Fluctuating disability, Hallucination, Decreased blood pressure, Decreased white blood cell count, Increased liver enzymes, Reduced blood platelets, Vomiting.
Expert advice for Benserazide
• Inform your doctor if you are going to have an operation. You may be asked to stop this medication before administering general anesthetic.
• Tell your doctor if you have been advised to undergo any laboratory test as this medicine may affect the results of some tests.
• Use effective methods of contraception while taking this medication to avoid pregnancy.
• Do not stop taking this medicine abruptly without your doctor’s advice. Sudden withdrawal of this medicine may lead to a serious life-threatening condition called as ‘neuroleptic malignant-like syndrome ’, symptoms include increased shaking, sudden high body temperature and muscle problems including stiffness and trouble with balancing.
• Do not drive or operate machinery as benserazide may cause dizziness, sudden onset of sleep/excessive sleepiness and visual disturbances.
• Should not be given to patients who are allergic to benserazide or any of its ingredients.
• Should not be given to patients under 25 years of age.
• Should not be given to patients with liver, kidney or heart disease (e.g. uneven heartbeat or heart attack).
• Should not be given to patients with hormonal disorders (e.g. overactive thyroid gland).
• Should not be given to patients with psychiatric problems which may include anxiety, inability to think and judge correctly, hallucinations etc. or are being treated with anti-depressants (non-selective monoamine oxidase inhibitors.
• Should not be given to patients who have a history of or may be suffering from skin cancer.
• Should not be given to patients having problems of  pressure in eyes (narrow angle glaucoma).
• Should not be given to pregnant women.
Q. Why is benserazide administered with levodopa?
Benserazide on its own has little therapeutic effect but it works synergistically in combination with levodopa.
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