Side Effects:

Common Headache, Nausea, Nasopharyngitis, Flushing (sense of warmth in the face, ears, neck and trunk), Dyspepsia, Muscle pain, Back pain, Pain in extremity.

Expert advice for Zydalis Tablet MD
Take it when you need it. Do not take more than once a day. It's best to take Zydalis about 1 hour before sexual intercourse, but you can take it anywhere between 30 minutes and 4 hours before sexual activity. Zydalis helps achieve and maintain an erection, but will not produce the erection without sexual stimulation.  Do not use Zydalis if you have recently taken nitrates (medicines used in angina or chest pain). Notify your doctor if the erection persists for more than two hours after sexual intercourse.  Do not take Zydalis if you recently had a stroke, a heart attack or if you have a serious liver disease or very low blood pressure (

Frequently Asked Questions

Q. Is Zydalis addictive?
No, Zydalis is not an addictive drug. However, some people may develop an emotional or psychological dependence on the medicine. Always take the medicine for the duration as suggested by your doctor.

Q. Can I take Zydalis with prednisone?
Zydalis, when taken with prednisone, may cause low blood pressure. Please consult your doctor for the change of dose regimen or an alternative drug of choice that may be required when the two medicines are to be used together.

Q. Is Zydalis safe to use?
Zydalis is safe when used strictly as advised by your doctor and for approved conditions like erectile dysfunction and pulmonary arterial hypertension. However, there are some very common side effects that you may experience with Zydalis like a headache, flushing, nasal congestion, dyspepsia, back pain, muscle pain, and pain in extremity.

Q. Is Zydalis better than sildenafil?
Both Zydalis and sildenafil belong to the same group of drugs called phosphodiesterase 5 inhibitors, used for the treatment of erectile dysfunction and pulmonary arterial hypertension. However, Zydalis has a slow onset of action with less efficacy but works for a much longer time and is safer than sildenafil.

Q. How long can I take Zydalis for?
Zydalis should only be taken only for the time period as advised by your doctor.

Q. Can I take Zydalis with losartan?
Yes, Zydalis can be taken with losartan. However, there could be an excessive fall in blood pressure when taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken when taking them together and inform your doctor if you experience any of these symptoms.

Q. Can I take Zydalis if I have high blood pressure?
Zydalis can be taken in patients with high blood pressure. However, if you are on medicines for high blood pressure, taking Zydalis along with them can cause a significant fall in blood pressure which could be harmful. Zydalis is absolutely contraindicated in patients taking nitrates. Inform your doctor before taking them together.

Q. Can I take Zydalis with antibiotics?
Zydalis can be taken safely with antibiotics. However, it is degraded in the body by an enzyme known as CYP3A4 and a dose adjustment may be needed when it is used with drugs which can affect the activity of this enzyme. Antibiotics like erythromycin, clarithromycin, ketoconazole and itraconazole can decrease the action of this enzyme and increase Zydalis levels in the blood. Antibiotics like rifampicin increase the action of this enzyme causing an increased breakdown of Zydalis and decrease its efficacy.

Q. Does Zydalis affect sperm count?
No, Zydalis has no known effect on sperm count. It is a medication used for erectile dysfunction, not to increase sperm count.

Q. Does Zydalis delay ejaculation?
No, Zydalis is not known to affect ejaculation. It is used for the treatment of erectile dysfunction.

Q. Does Zydalis expire?
Like any other drug, Zydalis does have an expiry date and should not be used beyond that. Please check the package insert for the same.

Q. Does Zydalis work?
Yes, Zydalis works very effectively for the treatment of erectile dysfunction and pulmonary arterial hypertension when taken strictly as advised by your doctor.

Q. How long does Zydalis last?
Generally, the effect of Zydalis lasts from 24 to 36 hours, however, the effect may vary from patient to patient. As it works for a long duration, its action may last for more than one day. Some patients call it a weekend pill which is when taken on Friday night, the effect may last until Sunday morning. So it is preferred over sildenafil and verdanafil by some patients.

Q. Is Zydalis a steroid?
No, Zydalis is not a steroid. It is a phosphodiesterase enzyme inhibitor and is used for treating erectile dysfunction.

Q. Is Zydalis same as sildenafil?
Both Zydalis and sildenafil belong to the same group of drugs called phosphodiesterase 5 inhibitors, used for the treatment of erectile dysfunction and pulmonary arterial hypertension. However, Zydalis has a slow onset of action with less efficacy but works for a much longer time and is safer than sildenafil.

Q. Can I take Zydalis forever?
No, Zydalis is not a life long medicine. It should be taken only for a duration as advised by the doctor.

Q. Can I take Zydalis just for fun?
Zydalis is a prescription drug and should only be taken for the appropriate indication as prescribed by a doctor as it may be associated with many side effects. Also, it is available only on prescription by a doctor.

Q. Can I take Zydalis with tamsulosin?
When taken together, these drugs may produce an additive blood-pressure-lowering effect. Dose needs to be titrated carefully. Consult your doctor before taking them together.

Q. Can I take Zydalis with lisinopril?
Yes, Zydalis can be taken with lisinopril. However, there could be an excessive fall in blood pressure when taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken when taking them together and inform your doctor if you experience any of these symptoms.

Q. Can I take Zydalis with metoprolol?
Yes, Zydalis can be taken with metoprolol. However, there could be an excessive fall in blood pressure when taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken when taking them together and inform your doctor if you experience any of these symptoms.

Q. Does Zydalis cure erectile dysfunction?
Zydalis is not a cure for erectile dysfunction. It only helps in erection by relaxing penile smooth muscles and increasing blood flow.

Q. Does Zydalis increase the size of the penis?
No, Zydalis is not known to increase the size of the penis.

Q. Does Zydalis lower blood pressure?
Zydalis can lower the blood pressure but does not have a significant effect. However, when used along with other medications which lower blood pressure, it can have an additional effect which can be harmful. Talk to your doctor in case you are taking blood pressure lowering medicines and you are also advised to take Zydalis.

Q. Does Zydalis increase testosterone?
Zydalis is not known to have any effect on testosterone levels. However, if your testosterone levels are low, then Zydalis may not be useful in treating erectile dysfunction.

Q. Can I take Zydalis with sildenafil?
Both Zydalis and sildenafil are phosphodiesterase inhibitors and act by dilating the blood vessels. Using them together would not give any additional benefit, rather they may cause a severe fall in blood pressure and a prolonged painful erection. Therefore, these two drugs should not be taken together.

Q. Can I take Zydalis when I am also taking bisoprolol?
Yes, Zydalis can be taken with bisoprolol. However, there could be an excessive fall in blood pressure when they are taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken when taking both the drugs together and inform your doctor if you experience any of these symptoms.

Q. What will be the effect of using ibuprofen with Zydalis?
Yes,Zydalis can be taken with ibuprofen. It is used by many patients to relieve the headache caused by Zydalis. No drug-drug interactions or any harmful effects have been reported when they are used together.

Q. Is Zydalis use associated with nosebleed (epistaxis)?
Yes, there have been some reports where the patients have given the history of nose bleed (epistaxis) after taking Zydalis. Other drugs from the same class have also shown to cause nose bleeds in some patients.

Q. What is the difference between Zydalis and L-arginine?
Zydalis is used for the treatment of erectile dysfunction. It works by releasing nitrous oxide (NO) which relaxes the smooth muscles of the blood vessels and dilates them. L-arginine is an amino acid which is involved in the synthesis of nitric oxide (NO). So, it has been suggested that L-arginine can help in the treatment of erectile dysfunction. However, there is no regulatory approval for its use as of now.

Q. Are Zydalis and avanafil same?
No, Zydalis and avanafil are not same drugs but they belong to the same class of phosphodiesterase-5 (PDE5) inhibitors used for the treatment of erectile dysfunction. Zydalis is also used in the treatment of pulmonary arterial hypertension in lower doses. Zydalis is seen to be more efficacious, better tolerated and longer acting than avanafil. However, avanafil starts to show its effect faster than Zydalis.

Q. How is Zydalis different from vardenafil?
Both Zydalis and vardenafil are phosphodiesterase-5 (PDE5) inhibitors used in the treatment of erectile dysfunction (ED). Zydalis is also used in the treatment of pulmonary arterial hypertension in lower doses. Zydalis starts to act in 20 minutes but the action remains for almost 36 hours whereas vardenafil starts to act in 10 minutes and acts for almost 10 hours, respectively. Zydalis is less effective than vardenafil but safer.

Q. Is it safe to take Zydalis with amlodipine?
Yes, Zydalis can be taken with amlodipine. However, there could be an excessive fall in blood pressure they are when taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken and inform your doctor if you experience any of these symptoms.

Q. Is it safe to take Zydalis with propranolol?
Yes, Zydalis can be taken with propranolol. However, there could be an excessive fall in blood pressure they are when taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken and inform your doctor if you experience any of these symptoms.

Q. Can I take Zydalis when I am also taking atenolol for controlling my blood pressure?
Yes, Zydalis can be taken with atenolol. However, there could be an excessive fall in blood pressure they are when taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken and inform your doctor if you experience any of these symptoms.

Q. Is it safe to take Zydalis when I am also taking fluconazole?
Zydalis can be taken with fluconazole, however, a dose adjustment would be needed before taking them together. Zydalis is metabolized (degraded) by an enzyme known as CYP3A4. Fluconazole decreases the working of this enzyme causing increased blood levels of Zydalis and higher chances of having side effects.

Q. Is Zydalis safe to use in patients with glaucoma?
Yes, Zydalis can be used by patients with glaucoma. But you must inform your doctor before using this medicine. It has been found to increase the intraocular pressure in animals whereas the same is not seen in humans. However, other medicines of this class have been reported to cause increase intraocular pressure in healthy human beings.

Q. Is it safe to take Zydalis with dapoxetine?
Yes, Zydalis can be safely taken with dapoxetine. Zydalis is useful for treating erectile dysfunction and dapoxetine is for premature ejaculation. A fixed dose combination of these medicines is available which is useful in patients suffering from both erectile dysfunction and premature ejaculation. No drug-drug interactions or any harmful effects have been reported when they are used together.

Q. Can I use Zydalis with nitroglycerin?
Use of Zydalis is not recommended in patients taking nitrates like nitroglycerin as their combined use can cause a severe fall in blood pressure, which can also result in death. It is advisable to keep a time gap of 24 hours between the intake of Zydalis and any nitrate substance.

Q. What is the benefit of taking Zydalis with finasteride?
Yes, Zydalis can be taken along with finasteride. This combination is beneficial in the treatment of benign prostatic hyperplasia (BPH). Finasteride is also known to cause erectile dysfunction as one of its side effects and Zydalis can be used for the treatment of this problem along with finasteride.

Q. Can I take Zydalis with grapefruit juice?
Zydalis can be taken with grapefruit juice, however, a dose adjustment would be needed before taking them together. Zydalis is metabolized (degraded) by an enzyme known as CYP3A4. Grapefruit juice decreases the working of this enzyme, increases blood levels of Zydalis leading to higher chances of side effects.

Q. Can I take Zydalis with tramadol?
Yes, Zydalis can be taken with tramadol. No drug-drug interactions or any harmful effects have been reported when they are used together.

Q. How safe is it to use Zydalis with paracetamol?
Yes, Zydalis can be taken with paracetamol. It is used by many patients to relieve a headache caused by Zydalis. No drug-drug interactions or any harmful effects have been reported when they are used together.

Q. Is Zydalis a nitrate?
No, Zydalis is not a nitrate. It belongs to a group of medicines called phosphodiesterase 5 inhibitors used for the treatment of erectile dysfunction.

Q. Is Zydalis a controlled substance?
Zydalis is not a controlled substance. It's a prescription medicine and is available on providing a valid prescription by a doctor.

Q. Is Zydalis a blood thinner?
No, Zydalis is not a blood thinner. It belongs to a group of medicines called phosphodiesterase 5 inhibitors used for the treatment of erectile dysfunction.

Q. Is Zydalis a prescription medicine?
Yes, Zydalis is a prescription medicine. It is available for providing a valid prescription by a doctor.