Mefliam Plus Tablet 
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USED FOR:
Malaria
COMPOSITION:
Artesunate (100mg)
Mefloquine (220mg)
Therapeutic Uses:
anti malarials
Interaction with alcohol is unknown. Please consult your doctor.
WEIGH RISKS VS BENEFITS
Mefliam Plus Tablet may be unsafe to use during pregnancy.Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Mefliam Plus Tablet is probably safe to use during lactation. Limited human data suggests that the drug does not represent a significant risk to the baby.
Do not drive unless you are feeling well.Mefliam Plus Tablet can cause dizziness, loss of balance and mental problems and this may affect your ability to drive.
There is limited information available on the use of Mefliam Plus Tablet in patients with kidney disease. Please consult your doctor.
CAUTION
Mefliam Plus Tablet should be used with caution in patients with liver disease. Dose adjustment of Mefliam Plus Tablet may be needed. Please consult your doctor.Use of Mefliam Plus Tablet is not recommended in patients with severe liver disease.
Uses of Artesunate
Artesunate is used in the treatment of malariaIt is not used to prevent malaria or to treat severe malaria (where it has affected the brain, lungs or kidneys).
How to use Artesunate
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it.
How Mefliam Plus Tablet works
Artesunate acts by producing free radicals within the malarial parasite, which kills it.
Common Decreased appetite, Headache, Vomiting, Abdominal pain, Cough.
Expert advice for Artesunate
Do not start or continue the artesunate tablets and consult your doctor If you are allergic (hypersensitive) to artesunate.Do not start or continue the artesunate tablets and consult your doctor you are in first 3 months of pregnancy  or If you are breast feeding.Do not drive or operate machinery after taking artesunate because you may feel sleepy.
Q. What is artesunate amodiaquine/ Winthrop/artesunate injection?
These are trade names of artesunate containing products. It is used for the treatment of malaria. Patients should follow the advice of the doctor regarding its use
Q. Does artesunate contain sulphur?
No, it does not contain sulphur
Q. Where does Artesunate come from?
It is derived from Artemisinin tree.
Q. Is Artesunate banned in India?
No, it is available in India with doctor's prescription only
Q. Why is artesunate better than quinine?
Intramuscular or intravenous injection of artesunate has shown better treatment effects than quinine. Always consult your doctor regarding its use
Q. How does Artesunate work?
It acts by producing free radicals which kills the malarial parasite (Plasmodium)
Uses of Mefloquine
Mefloquine is used in the treatment of malaria.
How to use Mefloquine
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it.
How Mefliam Plus Tablet works
Mefloquine is a weak base that reaches high concentration within the malarial parasite and causes accumulation of toxic heme pigment, which kills it.
Common Abdominal pain, Abnormal dreams, Anxiety, Chills, Depression, Diarrhoea, Dizziness, Fever, Headache, Altered heart rate, Insomnia (difficulty in sleeping), Itching, Loss of appetite, Muscle pain, Nausea, Rash, Ringing in ear, Vertigo, Visual impairment, Vomiting, Fatigue.
Expert advice for Mefloquine
Consult your doctor before taking mefloquine if you have fits (seizures), any heart diseases or liver disorders.Seek immediate medical attention if you experience pain, burning, tingling, numbness in hands/feet and/or muscle weakness or problems in eyes or with vision after taking mefloquine.Do not drive or operate machinery while using mefloquine as it may cause dizziness and visual disturbances.Tell your doctor if you are or planning to become pregnant or are breastfeeding.
Q. Is Mefloquine safe?
Yes. Mefloquine is safe if used at the prescribed doses for the prescribed duration as advised by your doctor
Q. Is Mefloquine safe for babies?
It is not recommended for use in babies below 3 months and weighing less than 5 kg
Q. Is mefloquine an antibiotic/ a quinolone/ does it contain sulphur or sulfa/ contain quinine?
No. Mefloquine is an antimalarial drug with activity against malaria causing parasites. It is a quinine antimalarial and does not contain sulphur/ sulfa or quinolone
Q. Is mefloquine the same as doxycycline/ chloroquine?
No. Mefloquine is not the same as doxycycline or chloroquine. All three drugs have different mechanism of action and indications
Q. How does Mefloquine work?
Mefloquine is an antimalarial drug. It works by killing the malaria causing parasite by destroying the parasites at a crucial stage of development (asexual intraerythocytic stage)
Q. What does Mefloquine treat?
Mefloquine is used in the prevention and treatment of malaria
Q. Does Mefloquine cause insomnia?
Yes. Insomnia (difficulty falling asleep) is a common side effect of Mefloquine treatment
Q. Is Mefloquine safe for G6PD deficiency?
Yes. Studies have indicated that Mefloquine is safe for use in glucose-6-phosphate dehydrogenase (G6PD) deficiency.
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