Side Effects:

Common Fatigue, Drowsiness, Headache, Constipation, Diarrhoea, Muscle pain.

Expert advice for Peploc Tablet
Peploc is a well tolerated and safe medicine with a very low incidence of side effects. Take Peploc before going to bed if you are taking this medicine once a day as it is very effective in controlling stomach acid released in the midnight. If you are also taking an antacid, take it two hours before or after taking Peploc. Avoid taking soft drinks, citrus fruits like orange and lemon, which can irritate the stomach and increase acid secretion. Inform your doctor if you do not feel better after taking Peploc for two weeks or 14 days as you may be suffering from some other problems. Inform your doctor if you have ever been diagnosed with kidney or liver disease. Dose of your medicine may need to be adjusted.

Frequently Asked Questions

Q. Is Peploc an over the counter (OTC) drug?
No, Peploc is not an over-the-counter product. It is a prescription medicine and is available only when prescribed by a physician.

Q. Can I take Peploc with azithromycin?
Yes, Peploc can be taken with azithromycin. Peploc may be given to lower the acid secretion caused by gastritis or stomach irritation caused by azithromycin. No drug-drug interactions or any additional harmful effects have been seen when they are used together compared to when they are used alone.

Q. Can the use of Peploc cause constipation?
Yes, the use of Peploc can cause constipation. It is one of the common side effect seen with Peploc. Taking high fiber diet and plenty of fluids can help in relieving constipation and can also help in decreasing acidity.

Q. Can I take Peploc with prednisone?
Yes, Peploc can be taken with prednisone. No drug-drug interactions or any change in side effect profile have been when these are used together compared to when each drug is used alone.

Q. Can I take Peploc with metoprolol?
Yes, Peploc can be taken with metoprolol. No drug-drug interactions or any change in side effect profile have been reported compared to when they are used alone.

Q. Is Peploc an antacid?
No, Peploc is not an antacid. It belongs to the class of H2 blockers (antihistamines) which decrease the amount of acid produced in the stomach while antacids only neutralize the stomach acid by coating the stomach.

Q. Can I take Peploc for the treatment of allergies or hives (urticaria)?
Peploc can help in decreasing the redness of the allergies or hives (urticaria) when used along with antihistaminics like cetirizine by narrowing the blood vessels. However, this is not an approved use of Peploc and should be used only when advised by a doctor.

Q. Does Peploc expire?
Yes, Peploc does expire. Please check the expiry date written on the pack and it refers to the last day of that month. Do not use Peploc after the expiry date.

Q. Can I take Peploc with tramadol?
Yes, Peploc can be taken with the tramadol. Peploc may be given to lower the acid secretion caused by gastritis or stomach irritation caused by tramadol. No drug-drug interactions or any change in side effect profile has been reported compared to when they are used alone.

Q. Is Peploc an antihistaminic drug?
Yes, Peploc is an antihistaminic drug. It acts on histamine receptors in the stomach and blocks the action of a chemical messenger histamine (causes acid secretion in stomach) and hence decreases the acid production in the stomach.

Q. Is Peploc safe?
Yes, Peploc is safe if used at prescribed doses for the prescribed duration as advised by the doctor. However, there are some very common side effects that you can experience at the doses advised like nausea, abdominal pain, constipation, diarrhea, and flatulence.

Q. Can I take Peploc with doxycycline?
Yes, Peploc can be taken with doxycycline. Peploc may be given to lower the acid secretion caused by gastritis or stomach irritation caused by doxycycline. No drug-drug interactions or any change in side effect profile has been reported compared to when they are used alone.

Q. Does Peploc interfere with H. pylori test results?
A significant number of patients infected with Helicobacter pylori can have negative test results if they are using Peploc as it interferes with the urea breath test, which is done to identify H. Pylori infection.

Q. Can I take Peploc with Rabeprazole?
Yes, Peploc and Rabeprazole can be taken together. As Rabeprazole show its effect after some days, Peploc can be taken along with for immediate relief. No drug-drug interactions or change in side effect profile has been reported when they are used together compared to either drug alone.

Q. Can I take Peploc with sertraline?
Yes, Peploc can be taken with sertraline. No drug-drug interactions or any change in side effect profile has been reported compared to the effect of the individual drug when used alone.

Q. Does Peploc cause glaucoma?
Peploc itself does not cause glaucoma. However, there are some rare reports that Peploc can increase the intraocular pressure in patients who have glaucoma. Inform your doctor in case you have glaucoma or high intraocular pressure before taking this medicine.

Q. Can I take Peploc with steroids?
Yes, Peploc can be taken with steroids. No drug-drug interactions or any change in side effect profile has been reported compared to the effect of the individual drug when used alone.

Q. Can I take Peploc with famotidine?
Both Peploc and famotidine lower gastric acid secretion by blocking the H2 (histamine) receptor in the stomach. It is not advisable to take them together as they have a similar action and use and when used together, there could be an increased risk of side effects.

Q. Can Peploc be used to treat gastritis?
Yes, Peploc can be used for the short-term treatment of gastritis. It helps by decreasing the amount of acid released into the stomach and relieving stomach pain and acid reflux.

Q. Can I take Peploc with vitamin B?
Yes, Peploc can be taken with vitamin B. No drug-drug interactions have been reported between this medicine and vitamin B.

Q. Can a patient of hepatitis B take Peploc?
Caution should be exercised when Peploc is given to patients with a liver disease like hepatitis B as it is metabolized in the liver. Peploc can be taken by a patient of hepatitis B if it is really essential and advised by a doctor. Very rare reports of hepatitis with or without jaundice have been documented in patients taking Peploc.

Q. Why Peploc is given along with vitamin B12?
Long term use of Peploc can cause vitamin B12 deficiency as it decreases the acid secretion in the stomach which is required for the absorption of Vitamin B12. To prevent this deficiency, vitamin B12 may be advised by your doctor along with this medicine.

Q. Can I take Peploc with vitamin C?
Yes, you can take Peploc with vitamin C. No drug-drug interactions or change in side effect profile has been reported when they are used together compared to either drug alone.

Q. Can a patient with hepatitis C take Peploc?
Yes, a patient of hepatitis C can take Peploc, however, this should be taken under medical supervision. Peploc belongs to the group of drugs called H2 blockers which have been seen to increase the risk of hepatic encephalopathy in hepatitis C patients. So, this group of medicines should be used with caution in patients with underlying liver disease.

Q. Can Peploc be used with vitamin D?
Yes, vitamin D can be taken with Peploc. It is generally advised to be taken as a supplement as the long-term use of Peploc decreases the absorption of calcium and cause calcium deficiency leading to osteoporosis (thinning of bones) and increasing the risk of bone fractures like hip, wrist and spine fractures.

Q. Can the use of Peploc cause gastroparesis (partial paralysis of the stomach)?
No, the use of Peploc is not known to cause gastroparesis (partial paralysis of the stomach), however in case you experience signs and symptoms of gastroparesis like persistent nausea, vomiting (especially of undigested food) and abdominal pain or a feeling of fullness after eating even small amount of food, consult your doctor as it may be due to some condition that needs attention.

Q. Can the use of Peploc make you feel high?
No, Peploc does not make you feel high. However, use of Peploc can cause mental confusion, irritability, depression, though very rarely. These undesirable side effects occur usually in elderly or severely ill or kidney disease patients.

Q. Can the use of Peploc cause high blood pressure?
Peploc is not reported to cause high blood pressure. In case you experience high blood pressure,inform your doctor as it may need attention. Common side effects seen with Peploc include nausea, abdominal pain, constipation, and diarrhea.

Q. Can I use Peploc for treating warts?
No, Peploc is not used for treating warts as it is not approved for this disease condition. However, some research studies have shown that Peploc can improve the effect of medicines used for the treatment of this condition. Warts are a viral condition in which the patient has small, rough, and hard growths like raised bumps on the skin. Avoid self-medication and talk to a doctor for the right treatment of warts as it may bleed or get infected or spread to other body parts if not treated properly.

Q. Can I use Peploc for stomach pain?
Stomach pain can be due to many reasons and Peploc can help in this condition if the stomach pain is due to an underlying acid-peptic disorder.

Q. Can the use of Peploc cause headache?
Headache is reported as one of the common side effects of Peploc. Inform your doctor in case you experience headache for a prolonged duration while taking Peploc.

Q. Why does Peploc cause pneumonia?
Patients using Peploc are two times more prone to develop pneumonia (infection of the lung) than the normal patients. Peploc by means of its acid suppressing ability may allow growth of bacteria in the gut which can move to the respiratory tract (lungs) following breathing. So inform your doctor if you have or a history of lung disease as your dosage may need to be adjusted.

Q. What is the role of Peploc in critically ill patients?
Peploc may be used in critically ill patients to decrease stomach acid secretion and lower the risk of acid aspiration into the lungs. It also helps in decreasing stomach ulcers and gastrointestinal bleeding in these patients.

Q. What foods should be avoided when you are taking Peploc?
You should preferably avoid foods that cause acidity and heartburn as they would aggravate your disease condition, for example: fried foods, prepared in butter or oil, fat rich foods, tomato-based foods and juices, caffeinated drinks like cola, tea, drinks from citrus fruits like lemon water or orange juice and alcohol-containing drinks.

Q. Can Peploc be used for reflux esophagitis?
Yes, Peploc is effective in the treatment of reflux esophagitis. It is a disease in which stomach acid or bile irritates and inflames the lining of the food pipe. Peploc decreases the production of acid in the stomach and this can help to heal the inflamed and eroded esophagus. The efficacy is better when it is given in combination with a prokinetic agent like domperidone.

Q. Can I take Peploc with paracetamol?
Yes, you can take Peploc with paracetamol. Peploc is used to prevent paracetamol (painkillers) induced gastritis and stomach ulcers by decreasing the production of acid in the stomach. There are no clinically significant drug-drug interactions or harmful effects seen when they are used together.

Q. Why is Peploc given with cancer drugs?
Peploc may be used for multiple reasons in cancer patients. It can lower stomach acid volume in patients undergoing chemotherapy to prevent aspiration and lower the risk of stomach ulceration and bleeding. According to some studies, Peploc can potentiate white blood cell against cancer cells and can be helpful in the treatment of cancer.

Q. Does Peploc treat irritable bowel syndrome (IBS)?
Peploc is not routinely used for the treatment of irritable bowel syndrome (IBS). It is given if there is associated dyspepsia or increased stomach acid secretion. IBS is managed with a combination of antispasmodics (to relieve stomach pain), laxatives (to relieve constipation), and anti motility drugs (to relieve diarrhea).

Q. Is Peploc used to treat nausea?
Peploc is used for the treatment of acidity, heartburn, intestinal ulcers and stomach ulcers and can help in providing relief in nausea that may happen due to acid reflux. It is not used to treat nausea due to any other cause. Rather, nausea is one of the most common side effects of Peploc.

Q. What is the benefit of taking Peploc with pantoprazole?
Both Peploc and pantoprazole lower gastric acid secretion, however, they work by different mechanisms. If you have been advised to take pantoprazole, you can also take Peploc initially for rapid relief of heartburn and acid reflux as pantoprazole may take a few days to show its effect and provide relief.

Q. Can I take Peploc with pain killers?
Yes, Peploc can be taken with painkillers. Peploc can help to prevent painkillers induced gastritis and stomach ulcers by decreasing the production of acid in the stomach. Moreover, there are no clinically significant interactions of Peploc with painkillers.

Q. What are the serious side effects associated with the use of Peploc?
Some serious side effects associated with the use of Peploc are bone marrow hypoplasia (decreased formation of blood cell components), anaphylactic shock (severe allergic reactions) sinus bradycardia (lowering of heart rate) and acute pancreatitis (inflammation of the pancreas).

Q. Why does Peploc cause diarrhea?
Use of Peploc lowers the natural stomach acid which normally helps to kill bacteria. So, use of Peploc leads to overgrowth of the harmful bacteria like clostridium difficile which can cause diarrhea. This is known as clostridium difficile–associated diarrhea (CDAD). Inform your doctor if you have loose stools many times in a day and for many days with stomach cramps and fever.

Q. Is Peploc effective?
Peploc would be effective only if used for the right indication in the dose and for the duration as advised by the doctor. In case you do not find any change in your disease condition while taking this medicine, please talk to your doctor. Do not change the dose or stop taking the medicine without consulting your doctor.

Q. Is Peploc useful in the prevention of painkiller (NSAID) induced gastric ulcers?
Yes, Peploc is useful for the prevention of painkiller (non-steroidal anti-inflammatory drug - NSAID) induced gastric ulcers. These may cause dull pain in the stomach, sudden weight loss, loss of appetite, nausea, vomiting or bloating. Avoid stress and spicy foods as they can make your symptoms worse.

Q. Can I smoke while taking Peploc?
It is better to avoid cigarette smoking when you are taking Peploc. As studies have shown that the effectiveness of Peploc is lower in smokers compared to non-smokers. Moreover, smoking may add to gastric problems leading to more production of gastric acid.

Q. Does Peploc increase uric acid levels and cause gout-like symptoms?
Peploc can increase blood uric acid levels and cause gout-like symptoms like pain, redness, and inflammation of joints and cause difficulty in movement of joints. Regular monitoring of uric acid levels may be advised if you are taking this medicine for a long term.

Q. Can I take Peploc with warfarin?
Yes, Peploc can be taken with warfarin. However, they should be used with caution as there could be an increase in warfarin levels which can increase the risk of bleeding from your gums, nose, skin (unusual bruising), or gut (dark stools). Stop taking the medicine and inform your doctor if you have any of these signs or symptoms.

Q. Can I take Peploc with gabapentin?
Yes, Peploc can be taken with gabapentin. There are no reported drug interactions or harmful effects when they are used together.

Q. Can I take Peploc with cetirizine?
Yes, Peploc can be taken with cetirizine. There are no reported drug interactions or harmful effects when they are used together.

Q. Is Peploc a proton pump inhibitor (PPI)?
No, Peploc is not a proton pump inhibitor (PPI) as it has no known inhibitory effect on proton pumps in the stomach.

Q. Can the use of Peploc cause iron deficiency?
Yes, use of Peploc can cause iron deficiency and a decrease in hemoglobin levels as it decreases the acidic environment of the stomach needed for the absorption of iron. However, there are no recommendations on the regular monitoring of iron levels or taking iron supplements when the patient is taking Peploc but you can maintain good dietary nutrition so that no deficiency occurs.

Q. Is there any known role of Peploc before surgery?
Peploc is given as a part of pre-anesthetic medication before surgery to decrease the stomach acid secretion so that stomach acid is not aspirated into the lungs during surgery as this may complicate or delay the procedure.

Q. Does Peploc cause flatulence (gas or bloating)?
Flatulence (gas) has been reported as a common side effect of Peploc. Although it would be mild to moderate in nature and it goes away once you stop taking Peploc.