Side Effects:

Common Nausea, Frequent urge to urinate, Increased thirst, Urinary tract infection, Hypoglycaemia (low blood sugar level) in combination with insulin or sulphonylurea, Genital fungal infection.

Expert advice for Oxra Tablet
Oxra is used together with other diabetes medicines to control blood sugar and avoids long-term complications. You should continue to exercise regularly, eat a healthy diet, and take your other diabetes medicines along with Oxra. Oxra also helps reduce weight and blood pressure. Oxra may cause you to urinate more often, so make sure you stay hydrated. Can cause genital fungal and/or urinary tract infections (UTIs) in both females and males. Can cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal.

Frequently Asked Questions

Q. Can I stop taking Oxra at once?
Do not stop taking Oxra at once. This can lead to a sudden increase in your blood glucose levels. Always follow the advice of your doctor for the dose and duration of your treatment. Never stop taking any medicine without consulting your doctor.

Q. Can Oxra help in the management of type 1 diabetes mellitus?
Oxra is not indicated for use in patients with type 1 diabetes mellitus. This medicine works by removing glucose through the urine and also increases the urine frequency which can worsen dehydration in these patients. There have been reports of diabetic ketoacidosis with Oxra, a complication seen in type 1 diabetic patients which may also get worsened in these patients.

Q. How is Oxra different from sitagliptin?
Both Oxra and sitagliptin are anti-diabetic drugs, but they work in different ways. Oxra is reported to be more effective in controlling blood sugar levels and also help in weight loss while sitagliptin is weight neutral. They also differ in their side effect profile as the use of sitagliptin is associated with nausea, nasopharyngitis, and pancreatitis while Oxra commonly causes urinary and genital tract infections.

Q. Can I take Oxra with metformin?
Yes, Oxra can be taken with metformin. A combined use of the two medicines can significantly improve blood glucose levels and glycosylated hemoglobin (HbA1c) and help in weight loss as compared to when either of the medicine is taken alone. No change in side effect profile has been reported compared to when they are used alone.

Q. Can I take Oxra with sulfonylureas like glimepiride?
Oxra and sulfonylureas like glimepiride, gliclazide, glyburide or glibenclamide can be taken together as it can help in better control of blood sugar levels. Use of Oxra can also help in lowering the risk of weight gain caused by sulfonylureas. However, the risk of low blood sugar levels (hypoglycemia) can increase. Consult your doctor as dose adjustment may be needed.

Q. Can the use of Oxra help in decreasing weight?
Yes, Oxra can help in lowering weight. Oxra works by removing glucose through urine, so, calories are lost resulting in weight loss according to some clinical studies. When used along with a balanced diet and exercise, it effectively lowers blood glucose levels and help in weight loss in type 2 diabetes patients.

Q. Can the use of Oxra lead to vaginal thrush (a fungal infection of the vagina)?
Yes, Oxra can lead to vaginal thrush (fungal infection of the vagina). So, it should be used with caution in patients with a history of frequent genital infections. Cleanliness of the vagina and external genitals will lower the risk of infections. Inform your doctor if you have painful urination, redness, itching or swelling of your genitals while taking this medicine.

Q. How is Oxra different from liraglutide?
Both are anti-diabetic medicines and lower blood glucose levels effectively and also help to lower weight. However, they differ in many ways. Oxra is to be taken by mouth and it lowers blood glucose levels by removing glucose from the body through urine and can cause urinary and genital tract infection. While liraglutide is an injectable which lowers blood glucose levels by the release of insulin and its use is commonly associated with nausea and there have been rare reports of pancreatitis in patients using this medicine.

Q. How long can Oxra take to show improvement of my conditions?
Oxra starts to show its effect from the first dose itself, however, it shows its maximum effect after 1 week of starting the medicine.

Q. Is Oxra better than canagliflozin?
Both Oxra and canagliflozin belong to the same class of drugs and work by removing glucose from urine. However, some clinical studies reported that canagliflozin is more effective in removing a higher amount of glucose through urine in 24 hours than Oxra. Also, the use of Oxra is advised to be avoided in patients with bladder cancer.

Q. Is Oxra better than gliclazide?
Both Oxra and gliclazide are anti-diabetic drugs however, they work in different ways and have different side effect profile. Gliclazide commonly causes low blood sugar levels while the use of Oxra is associated with urinary tract and genital infections. Oxra causes low blood sugar levels mostly when taken with insulins or sulfonylureas and it helps in weight loss compared to gliclazide which causes weight gain.

Q. Is Oxra better than metformin?
Both Oxra and metformin are effective in lowering blood glucose levels, however, they work in different ways and have different side effect profile. Metformin restores the body's ability to use insulin, lowering the blood sugar levels whereas Oxra works by increasing the amount of glucose that gets passed out in the urine. Metformin commonly causes nausea, vomiting, altered taste, abdominal pain, loss of appetite while Oxra is associated with nausea, increased thirst, urinary and genital tract infections.

Q. Is Oxra effective?
Yes, Oxra is effective if used for the right indication in the dose and for the duration as advised by the doctor. In case you do not find any change in your disease condition while taking this medicine, please talk to your doctor. Do not change the dose or stop taking the medicine without consulting your doctor.

Q. Can Oxra be taken along with canagliflozin?
No, it is not advisable to take Oxra with canagliflozin. Both belong to the same class of anti-diabetic drugs and work in the same way. Together they may be more efficacious but there could also be an increased risk of side effects caused by them.

Q. Can the use of Oxra cause urinary tract infections?
Yes, urinary tract infections is a reported side effect of Oxra. So if you observe pain or burning sensation while urinating consult your doctor. Drinking plenty of fluids as this may reduce burning sensation.

Q. What effect does Oxra have on renal impairment?
Oxra is not recommended for use in patients with moderate to severe renal impairment with eGFR (estimated glomerular filtration rate) less than 60 mL/min/1.73m2. It may cause an increase in creatinine, phosphorus and parathyroid hormone (PTH) levels and can cause fall in blood pressure hypotension. So inform your doctor if you have an underlying kidney disease before taking this medicine.

Q. What is the effect of the Oxra on cancer?
There is no such effect reported on cancer but some studies have shown an increased risk of bladder cancer with Oxra so use is avoided in patients with a history of bladder cancer and along with drugs like pioglitazone.

Q. What are the contraindications to use of Oxra?
Use of Oxra is not recommended in patients with a history of serious hypersensitivity reaction to Oxra, severe kidney disease, end-stage kidney disease, or dialysis.

Q. Does Oxra worsen euglycemic diabetic ketoacidosis?
Oxra may worsen diabetic ketoacidosis (increased total body ketone concentration, metabolic acidosis, and very high blood sugar levels). Oxra is not advised to be taken in this condition. The patient may experience nausea, vomiting, anorexia, abdominal pain, excessive thirst, difficulty breathing, confusion, unusual fatigue or sleepiness. Inform your doctor if you have these signs-symptoms while taking this medicine.