Common Sleepiness, Increased heart rate, Weight gain, Blurred vision, Dryness in mouth, Constipation, Difficulty in urination, Orthostatic hypotension (sudden lowering of blood pressure on standing).

Expert advice for Sizonorm Plus Tablet
The main dose should be taken at night as this drug may produce drowsiness or sleepiness. It can take 4 to 6 weeks for Sizonorm plus to start working. You should continue the treatment for at least 6 months after you feel better to stop depression from coming back. If your doctor asks you to stop Sizonorm plus, you should reduce the dose slowly over 4 weeks. You should not discontinue it abruptly. Avoid driving or operating machinery as it may decrease alertness. Avoid consuming alcohol when taking the Sizonorm plus, as it may cause excessive drowsiness and calmness. The addiction/dependence potential of Sizonorm plus is very less. It may be extremely dangerous in overdose.

Q. How does trimipramine work?
Trimipramine works by increasing the amount of certain natural substances in the brain that are needed to maintain mental balance and elevate mood.