Common Loss of appetite, Nausea, Vomiting, Gastric irritation, Orthostatic hypotension (sudden lowering of blood pressure on standing), Depression, Weakness, Sleepiness.

Expert advice for Prothicid Tablet
• Prothionamide is not recommended in children under 14 years of age.
• Tell your doctor before taking prothionamide if you have or had diabetes, fits, depression, other mental illness, severe kidney disease, liver problems, or vision problems.
• Take precautions if you have a history of mental disorders as prothionamide may cause excitability.
• You may be monitored with blood tests for changes in levels of blood sugar, liver function, and thyroid function tests and examination of vision, while on treatment with prothionamide.
• Do not consume alcohol during prothionamide therapy as it may worsen the side effects.
• Should not be given to patients allergic to prothionamide or any of its ingredients.
• Should not be given to patients with stomach and / or duodenal ulcer,  diseases of the gut causing recurrent ulcers in the gut, abdominal pain, recurrent diarrhea/ dysentery, (ulcerative colitis).
• Should not be given to pregnant and breastfeeding women.
• Should not be administered to patients with severe liver disease.
• Should not be given to patients with alcohol dependence.