Side Effects:

Common Headache, Diarrhoea, Dyspepsia, Flushing (sense of warmth in the face, ears, neck and trunk), Pain in extremity.

Expert advice for Instarise Tablet
Take it when you need it. Do not take more than once a day. It's best to take Instarise about 1 hour before sexual intercourse, but you can take it anywhere between 30 minutes and 4 hours before sexual activity. Instarise helps achieve and maintain an erection, but will not produce the erection without sexual stimulation.  Do not use Instarise if you have recently taken nitrates (medicines used in angina or chest pain). Notify your doctor if the erection persists for more than two hours after sexual intercourse.  Do not take Instarise if you recently had a stroke, a heart attack or if you have a serious liver disease or very low blood pressure (

Frequently Asked Questions

Q. How does Instarise work?
Instarise is a phosphodiesterase 5 inhibitor which works by relaxing the penile smooth muscles and by increasing the blood flow to the penis. It helps to achieve and maintain an erection but only if there is sexual stimulation.

Q. Is Instarise safe?
Yes, Instarise is safe if taken for prescribed duration in prescribed doses as advised by your doctor. However, there are some very common side effects that you can experience at effective doses like Headache, Diarrhoea, Dyspepsia, Flushing (sense of warmth in the face, ears, neck and trunk), Pain in Extremity.

Q. Is Instarise a steroid?
No, Instarise is not a steroid. It belongs to a group of medicines called phosphodiesterase 5 inhibitors used for the treatment of erectile dysfunction.

Q. Is Instarise an over the counter product?
No, Instarise is not an over-the-counter product. You can buy it when it is prescribed by a doctor.

Q. Is Instarise a blood thinner?
No, Instarise is not a blood thinner. It belongs to a group of medicines called phosphodiesterase 5 inhibitors used for the treatment of erectile dysfunction.

Q. Can I take Instarise for premature ejaculation?
Instarise is not known to have any beneficial effects of treating premature ejaculation. It is used for the treatment of erectile dysfunction.

Q. Can I take Instarise for the rest of my life?
Instarise is a prescription drug and should only be taken for the duration as advised by your doctor.

Q. Can I take Instarise in my twenties?
Yes, Instarise can be taken in the twenties. It is approved for use in adult men above the age of 18 who have erectile dysfunction. It should be taken after consulting a doctor and strictly as advised.

Q. Can I take Instarise with dapoxetine?
Yes, Instarise can be safely taken with dapoxetine. Instarise is useful for treating erectile dysfunction and dapoxetine is for premature ejaculation. A fixed dose combination of these medicines is available which is useful in patients suffering from both erectile dysfunction and premature ejaculation. No drug-drug interactions or any harmful effects have been reported when they are used together.

Q. Can I take Instarise with warfarin?
Instarise can be taken with warfarin, no significant drug interactions have been seen between the two. However, there have been some clinical reports of penile fracture in patients using Instarise with warfarin. Inform your doctor before taking the two drugs together.

Q. Can I take Instarise if I am also having high blood pressure?
Instarise can be taken in patients with high blood pressure. However, if you are taking medicines for high blood pressure, taking Instarise along with them can cause a significant fall in blood pressure which could be harmful. Instarise is absolutely contraindicated in patients taking nitrates. Inform your doctor before taking them together.

Q. Can I take Instarise with lisinopril?
Yes, Instarise can be taken with lisinopril. However, there could be an excessive fall in blood pressure when taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken when taking both the drugs together and inform your doctor if you experience any of these symptoms.

Q. Can I take Instarise with ramipril?
Yes, Instarise can be taken with ramipril. However, there could be an excessive fall in blood pressure when taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken when taking both the drugs together and inform your doctor if you experience any of these symptoms.

Q. Can I take Instarise with beta blockers?
Yes, Instarise can be taken with beta-blockers. However, there could be an excessive fall in blood pressure when taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken when taking both the drugs together and inform your doctor if you experience any of these symptoms.

Q. Can I take Instarise with amlodipine?
Yes, Instarise can be taken with amlodipine. However, there could be an excessive fall in blood pressure when taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken when taking both the drugs together and inform your doctor if you experience any of these symptoms.

Q. Does Instarise affect fertility?
No, Instarise is not known to affect fertility. It is used only for erectile dysfunction. For treatment of any fertility-related problems, please consult a doctor.

Q. Does Instarise affect sperm?
Instarise is not known to affect sperm (number or movement of sperms). It is a drug which is used for erectile dysfunction.

Q. Does Instarise increase blood pressure?
No, Instarise is not associated with an increase in blood pressure. It can cause a decrease in blood pressure especially if taken with other blood-pressure-lowering medications. Please consult your doctor before taking Instarise with any other medicine.

Q. Does Instarise delay ejaculation?
No, Instarise is not known to affect ejaculation.

Q. Does Instarise expire?
Instarise like any other medicine has an expiry date and should not be used beyond the date mentioned on the package.

Q. Why does Instarise cause a fall in blood pressure (hypotension)?
Instarise has the property of relaxing the smooth muscle of the blood vessels and widening them which can cause a fall in blood pressure (hypotension). So, when used with blood pressure lowering drugs or nitrates, it can cause a severe fall in blood pressure, which could be fatal. Instarise should not be taken if you are taking nitrates for chest pain or you have a history of heart attack or stroke in the past six months.

Q. Is Instarise safe to use in patients with diabetes?
Yes, Instarise is safe to use in patients with diabetes. Erectile dysfunction and is commonly reported by diabetic patients as diabetes is one of the most common causes of this condition. Long standing diabetes can damage the nerves in the body (neuropathy) including the nerves of the penis. It also harden and narrow the blood vessels which decreases the blood flow to the penis causing erectile dysfunction. Instarise is seen to be beneficial in treating erectile dysfunction (ED) in patients with diabetes mellitus.

Q. Why is the use of Instarise contraindicated with nitrates?
Use of Instarise is not recommended in patients taking nitrates (organic nitrates or organic nitrites) as their combined use can cause a severe fall in blood pressure, which can also result in death. It is advisable to keep a time gap of 24 hours between the intake of Instarise and any nitrate substance.

Q. What are the serious side effects of Instarise?
Instarise can cause serious side effects like heart attack, sudden cardiac death, abnormal heart beat and bleeding in the brain tissues that can cause temporary or permanent brain damage. A patient can have chest pain during the intercourse and if this occurs, try to relax in a semi-sitting position and do not use any nitrate to relieve the chest pain. Rarely a sudden loss in vision and serious allergic skin reactions with fever, peeling and swelling of the skin, blistering of the mouth, genitals and around the eyes can occur.

Q. Can I take Instarise for treating piles (hemorrhoids)?
No, Instarise is not indicated for the treatment of piles (hemorrhoids). Rather, its use has been reported to cause piles (hemorrhoids).

Q. Can Instarise be taken with losartan?
Yes, Instarise can be taken along with losartan. However, there could be an excessive fall in blood pressure when taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken when taking both the drugs together and inform your doctor if you experience any of these symptoms.

Q. Can I take Instarise with paracetamol?
Yes, Instarise can be taken with paracetamol. No drug-drug interactions or any harmful effects have been reported when they are used together.

Q. Can I take Instarise with aspirin?
Yes, Instarise can be taken with aspirin. No drug-drug interactions or any harmful effects have been reported when they are used together.

Q. Can Instarise increase the level of testosterone?
Yes, Instarise can increase the testosterone levels. It has a direct effect on the testes which can lead to an increase in the blood testosterone levels.

Q. Can Instarise cause persistent and painful erection of the penis (priapism)?
Instarise and other drugs used for the treatment of erectile dysfunction have been seen to cause prolonged erections and persistent and painful erection of the penis(priapism). In case the erection persists for more than 4 hours, immediately seek medical attention. If it is not treated immediately, penile tissue damage and permanent loss of potency can occur.

Q. Can Instarise be taken with itraconazole?
Instarise can be taken with itraconzole, however, a dose adjustment would be needed before taking them together. Instarise is metabolized (degraded) by an enzyme known as CYP3A4. Itraconazole decreases the working of this enzyme causing increased blood levels of Instarise and higher chances of having side effects.

Q. Can I take Instarise with tadalafil?
Both tadalafil and Instarise are phosphodiesterase inhibitors and act by dilating the blood vessels. Using them together would not give any additional benefit, rather they may cause a severe fall in blood pressure and a prolonged painful erection. Therefore, these two drugs should not be taken together.

Q. What is the benefit of taking Instarise with finasteride?
Yes, Instarise can be taken along with finasteride. This combination is beneficial in the treatment of benign prostatic hyperplasia (BPH). Finasteride is also known to cause erectile dysfunction as one of its side effects and Instarise can be used for the treatment of this problem along with finasteride.

Q. Can I take Instarise with Tamsulosin?
Special caution needs to be taken when Instarise is taken along with Tamsulosin. Both are known to decrease blood pressure and can also cause orthostatic hypotension (fall in blood pressure when standing from a sitting position). So, when taken together they can cause a severe fall in blood pressure which can be harmful.

Q. Is Instarise a prescription medicine?
Yes, Instarise is a prescription medicine and can be taken only when prescribed by the doctor.

Q. Can I take Instarise for fun?
Instarise is a prescription drug and should only be taken for the appropriate indication as prescribed by a doctor as it may be associated with its own side effects.