Glimepiride+Metformin+Pioglitazone is used in the treatment of type 2 diabetes.

This is a combination of three antidiabetic medicines: Glimepiride, metformin, pioglitazone. They work by different mechanisms to provide better control of blood sugar when single or dual therapy is not effective. Glimepiride is a sulfonylurea which works by increasing the amount of insulin released by the pancreas to lower the blood glucose. Metformin is a biguanide which lowers glucose production in the liver, delays glucose absorption from intestines and increases the body's sensitivity to insulin. Pioglitazone is a thiazolidinedione which also increases the body's sensitivity to insulin.

Hypoglycemia (low blood sugar level), Nausea, Altered taste, Diarrhoea, Stomach pain, Headache, Edema, Weight gain, Anemia, Blurred vision, Bone fracture, Upper respiratory tract infection