Oxyphenonium is used in the treatment of pain due to smooth muscle spasm
It is used in pain due to intestinal and stomach ulcers.

Oxyphenonium action is achieved via a dual mechanism: (1) a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites and (2) a direct effect upon smooth muscle (musculotropic).

Dryness in mouth, Excessive thirst, Arrhythmia, Reduced bronchial secretions, Increased heart rate, Palpitations, Dry skin, Photophobia, Loss of accommodation, Slow heart rate, Flushing (sense of warmth in the face, ears, neck and trunk), Dilatation of pupil, Difficulty in urination, Constipation