Pyrimethamine is used in the treatment of malaria.

Pyrimethamine is a weak base that reaches high concentration within the malarial parasite and causes accumulation of toxic heme pigment, which kills it.

Abnormal bruising, Abnormal skin pigmentation, Anemia, Change in blood test results, Dizziness, Headache, Vomiting, Weakness, Diarrhoea, Nausea

• Pyrimethamine when given with sulphonamide, it should be given with folic acid (vitamin) supplement.
• Do not use pyrimethamine if you are allergic to pyrimethamine or any other ingredient.
• Do not take pyrimethamine if you have megaloblastic anemia due to folate deficiency.
• Do not take pyrimethamine if you have kidney or liver problems; fits (seizures); depression; bone marrow problems; stomach or bowel problems (eg, malabsorption syndrome); phenylketonuria, or alcoholism.

Ques. Q. What is Pyrimethamine is used for?
Pyrimethamine is used to treat toxoplasmosis and treat or prevent malaria infections along with other medicines

Ques. Q. How does Pyrimethamine work?
Pyrimethamine is an antiparasitic and works by killing the parasites or preventing their growth in the blood stream.